{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE307nnn/GSE307213/"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE307213"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"CDK10 suppression sensitizes cells to CDK12/13 blockade","description":"A CRISPR screen with a CDK12/13 inhibitor identified CDK10 as a modulator of CDK12/13 blockade. CDK10 KO cells in OVCA and BRCA showed higher sensitivity to CDK12/13 inhibitors and increased apoptosis, compared to wild type cells. To investigate the effects on transcription, CDK10 KO cells with or without CDK12/13 inhibitor treatment were analyzed by RNA-sequencing.","dates":{"publication":"2026/06/09"},"accession":"GSE307213","cross_references":{"GSM":["GSM9219074","GSM9219052","GSM9219073","GSM9219051","GSM9219072","GSM9219050","GSM9219071","GSM9219093","GSM9219056","GSM9219078","GSM9219077","GSM9219055","GSM9219076","GSM9219054","GSM9219053","GSM9219075","GSM9219092","GSM9219070","GSM9219091","GSM9219090","GSM9219059","GSM9219058","GSM9219079","GSM9219057","GSM9219085","GSM9219063","GSM9219062","GSM9219084","GSM9219083","GSM9219061","GSM9219082","GSM9219060","GSM9219089","GSM9219067","GSM9219088","GSM9219066","GSM9219065","GSM9219087","GSM9219086","GSM9219064","GSM9219081","GSM9219080","GSM9219049","GSM9219048","GSM9219047","GSM9219069","GSM9219068","GSM9219046"],"GPL":["28038"],"GSE":["307213"],"taxon":["Homo sapiens"],"PMID":["[42270604]"]}}