GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE307nnn/GSE307213/primary200OKTranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE307213GEOGSEfalseCDK10 suppression sensitizes cells to CDK12/13 blockadeA CRISPR screen with a CDK12/13 inhibitor identified CDK10 as a modulator of CDK12/13 blockade. CDK10 KO cells in OVCA and BRCA showed higher sensitivity to CDK12/13 inhibitors and increased apoptosis, compared to wild type cells. To investigate the effects on transcription, CDK10 KO cells with or without CDK12/13 inhibitor treatment were analyzed by RNA-sequencing.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 sapiens[42270604]