{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE307nnn/GSE307225/"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"omics_type":["Other"],"species":["Homo sapiens"],"gds_type":["Other"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE307225"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Ultra-sensitive profiling of CRISPR-Cas off-target effects with Tracking-seq2","description":"Accurate detection of off-target activity in patient-derived cells is critical for ensuring the safety of gene therapeutics. Here, we present Tracking-seq2—the most sensitive, cell-based, and clinically applicable off-target detection technology to date, capable of profiling diverse genome editors. Crucially, we reveal that genomic variations drive distinct off-target heterogeneity across different cells, highlighting the necessity for personalized safety assessment in clinical genome editing therapies","dates":{"publication":"2026/06/16"},"accession":"GSE307225","cross_references":{"GSM":["GSM9716215","GSM9716216","GSM9716213","GSM9716214","GSM9716219","GSM9716217","GSM9716218","GSM9219419","GSM9219418","GSM9219417","GSM9219412","GSM9219411","GSM9219410","GSM9716211","GSM9219416","GSM9219415","GSM9716212","GSM9219414","GSM9716210","GSM9219413","GSM9716204","GSM9716205","GSM9716202","GSM9716203","GSM9716208","GSM9716209","GSM9716206","GSM9716207","GSM9219409","GSM9219408","GSM9219407","GSM9219406","GSM9219401","GSM9219400","GSM9716200","GSM9219405","GSM9716201","GSM9219404","GSM9219403","GSM9219402","GSM9716237","GSM9716238","GSM9716235","GSM9716236","GSM9219430","GSM9716239","GSM9219439","GSM9219434","GSM9716230","GSM9219433","GSM9219432","GSM9219431","GSM9716233","GSM9219438","GSM9219437","GSM9716234","GSM9716231","GSM9219436","GSM9219435","GSM9716232","GSM9716226","GSM9716227","GSM9716224","GSM9716225","GSM9716228","GSM9716229","GSM9219429","GSM9219428","GSM9219423","GSM9219422","GSM9219421","GSM9219420","GSM9219427","GSM9716222","GSM9219426","GSM9716223","GSM9716220","GSM9219425","GSM9716221","GSM9219424","GSM9716138","GSM9716259","GSM9716139","GSM9716136","GSM9716257","GSM9716137","GSM9716258","GSM9716251","GSM9716252","GSM9716250","GSM9716255","GSM9716256","GSM9716253","GSM9716254","GSM9716248","GSM9716249","GSM9716246","GSM9716247","GSM9716240","GSM9716241","GSM9716244","GSM9716245","GSM9716242","GSM9716243","GSM9716158","GSM9716159","GSM9716270","GSM9716273","GSM9716152","GSM9716153","GSM9716274","GSM9716150","GSM9716271","GSM9716151","GSM9716272","GSM9716156","GSM9716157","GSM9716154","GSM9716155","GSM9716149","GSM9716147","GSM9716268","GSM9716148","GSM9716269","GSM9716141","GSM9716262","GSM9716142","GSM9716263","GSM9716260","GSM9716140","GSM9716261","GSM9716145","GSM9716266","GSM9716267","GSM9716146","GSM9716264","GSM9716143","GSM9716144","GSM9716265","GSM9716170","GSM9716171","GSM9716174","GSM9716175","GSM9716172","GSM9716173","GSM9716178","GSM9716179","GSM9716176","GSM9716177","GSM9219481","GSM9219480","GSM9716169","GSM9219482","GSM9716160","GSM9716163","GSM9716164","GSM9716161","GSM9716162","GSM9716167","GSM9716168","GSM9716165","GSM9716166","GSM9219393","GSM9219392","GSM9219391","GSM9219390","GSM9219397","GSM9219396","GSM9219395","GSM9219394","GSM9716192","GSM9716193","GSM9716190","GSM9716191","GSM9716196","GSM9716197","GSM9716194","GSM9219399","GSM9219398","GSM9716195","GSM9716198","GSM9716199","GSM9716181","GSM9716182","GSM9716180","GSM9716185","GSM9219389","GSM9716186","GSM9716183","GSM9716184","GSM9716189","GSM9716187","GSM9716188","GSM9219452","GSM9219451","GSM9219450","GSM9219456","GSM9219455","GSM9219454","GSM9219453","GSM9219459","GSM9219458","GSM9219457","GSM9219441","GSM9219440","GSM9219445","GSM9219444","GSM9219443","GSM9219442","GSM9219449","GSM9219448","GSM9219447","GSM9219446","GSM9219470","GSM9219474","GSM9219473","GSM9219472","GSM9219471","GSM9219478","GSM9219477","GSM9219476","GSM9219475","GSM9219479","GSM9219463","GSM9219462","GSM9219461","GSM9219460","GSM9219467","GSM9219466","GSM9219465","GSM9219464","GSM9219469","GSM9219468"],"GPL":["29480"],"GSE":["307225"],"taxon":["Homo sapiens"]}}