GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE307nnn/GSE307276/primary200OKGenomicsHomo sapiensGenome variation profiling by SNP arrayhttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE307276GEOGSEfalseHigh-resolution mapping of IRF4 translocations in children and adults large B-cell lymphomas [Oncoscan CNV]Large B-cell lymphoma with IRF4 rearrangement (LBCL-IRF4) predominantly affects children and young adults (CAYA) presenting as localized disease with excellent prognosis. Although IRF4::IGH translocations are demonstrable in most tumors, cryptic rearrangements have been suggested. Next-generation sequencing (NGS) studies have identified a distinct mutational landscape. Whether large B-cell lymphomas (LBCL) harboring IRF4 rearrangements in adults represent the same biological entity remains uncertain. A total of 35 pediatric and young adult (CAYA) patients diagnosed with LBCL-IRF4 (38/42 positive by fluorescence-in-situ-hybridization, FISH) and 7 adult LBCL with IRF4-R were analyzed with integrative molecular approach.2026/09/01GSE307276GSM9220324GSM9220323GSM9220334GSM9220326GSM9220315GSM9220325GSM9220320GSM9220331GSM9220330GSM9220333GSM9220322GSM9220321GSM9220332GSM9220317GSM9220328GSM9220316GSM9220327GSM9220319GSM9220318GSM92203291860221558307276Homo sapiens[42466980]