{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE307nnn/GSE307279/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomics"],"species":["Homo sapiens"],"gds_type":["Genome variation profiling by SNP array"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE307279"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"High-resolution mapping of IRF4 translocations in children and adults large B-cell lymphomas [CytoScanHD_Array]","description":"Large B-cell lymphoma with IRF4 rearrangement (LBCL-IRF4) predominantly affects children and young adults (CAYA) presenting as localized disease with excellent prognosis. Although IRF4::IGH translocations are demonstrable in most tumors, cryptic rearrangements have been suggested. Next-generation sequencing (NGS) studies have identified a distinct mutational landscape. Whether large B-cell lymphomas (LBCL) harboring IRF4 rearrangements in adults represent the same biological entity remains uncertain. A total of 35 pediatric and young adult (CAYA) patients diagnosed with LBCL-IRF4 (38/42 positive by fluorescence-in-situ-hybridization, FISH) and 7 adult LBCL with IRF4-R were analyzed with integrative molecular approach.","dates":{"publication":"2026/09/01"},"accession":"GSE307279","cross_references":{"GSM":["GSM9220356","GSM9220353","GSM9220352","GSM9220355","GSM9220354"],"GPL":["16131"],"GSE":["307279"],"taxon":["Homo sapiens"],"PMID":["[42466980]"]}}