{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE307nnn/GSE307353/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE307353"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Siglec-F Protects Against Elastase-induced Lung Inflammation and Emphysema in Mice","description":"Airspace macrophages (AMs) are essential for maintaining lung homeostasis. Their activity must be tightly controlled to prevent excessive immune responses and tissue damage, such as emphysematous alveolar destruction. Siglec-F is a canonical marker of AMs, but its functional role in lung disease remains unclear. Here, we investigated the role of Siglec-F in a murine model of elastase-induced emphysema. We found that Siglec-F-deficient mice exhibited worsened emphysematous phenotypes, along with accumulation and transcriptional reprogramming of resident AMs (RAMs). Transcriptomic profiling of Siglec-F-deficient RAMs revealed dysregulation of key pathways involved in tissue repair, including extracellular matrix degradation, TGF-β signaling, and phagocytosis. These findings demonstrate that Siglec-F is critical for restraining RAM activity and preserving alveolar integrity during injury. Our study provides new insight into the immunoregulatory function of Siglec-F in a tissue-destructive context and highlights the potential protective roles of Siglec signaling in chronic lung disease.","dates":{"publication":"2026/02/24"},"accession":"GSE307353","cross_references":{"GSM":["GSM9222682","GSM9222683","GSM9222680","GSM9222681","GSM9222688","GSM9222689","GSM9222686","GSM9222687","GSM9222684","GSM9222685","GSM9222693","GSM9222694","GSM9222691","GSM9222692","GSM9222690","GSM9222679","GSM9222677","GSM9222699","GSM9222678","GSM9222697","GSM9222675","GSM9222698","GSM9222676","GSM9222695","GSM9222673","GSM9222674","GSM9222696"],"GPL":["28330"],"GSE":["307353"],"taxon":["Mus musculus"],"PMID":["[41000867]"]}}