{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE307nnn/GSE307415/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"," Homo sapiens"],"gds_type":[" Other","Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE307415"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Single-cell RNA and BCR sequencing of age-associated B cells in mouse and human lupus","description":"To characterize age-associated B cells (ABCs), we performed single-cell RNA and BCR sequencing on splenic B-lineage cells from a murine lupus model induced by Toll-like receptor 7 (TLR7) stimulation and on peripheral blood B-lineage cells from a treatment-naïve patient with systemic lupus erythematosus (SLE). We identified a population of ABCs with features of plasmablast precursors (pre-PB ABCs). In the TLR7-induced lupus model, B cell-specific Commd3 deletion reduced the frequency of pre-PB ABCs and was associated with increased apoptosis in this population.","dates":{"publication":"2026/06/03"},"accession":"GSE307415","cross_references":{"GSM":["GSM9223683","GSM9223684","GSM9223681","GSM9223682","GSM9223680","GSM9223687","GSM9223685","GSM9223686"],"GPL":["34284","24247","34290"],"GSE":["307415"],"taxon":["Mus musculus"," Homo sapiens"]}}