GEOTranscriptomicsMus musculus Homo sapiens OtherExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE307415GEOGSEfalseSingle-cell RNA and BCR sequencing of age-associated B cells in mouse and human lupusTo characterize age-associated B cells (ABCs), we performed single-cell RNA and BCR sequencing on splenic B-lineage cells from a murine lupus model induced by Toll-like receptor 7 (TLR7) stimulation and on peripheral blood B-lineage cells from a treatment-naïve patient with systemic lupus erythematosus (SLE). We identified a population of ABCs with features of plasmablast precursors (pre-PB ABCs). In the TLR7-induced lupus model, B cell-specific Commd3 deletion reduced the frequency of pre-PB ABCs and was associated with increased apoptosis in this population.2026/06/03GSE307415GSM9223683GSM9223684GSM9223681GSM9223682GSM9223680GSM9223687GSM9223685GSM9223686342842424734290307415Mus musculus Homo sapiens