GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE307nnn/GSE307668/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE307668GEOGSEfalseEffect of TTYH2 Knockout on Gene Expression During DMXAA Treatment in Mouse Peritoneal Macrophages [RNA-seq]Beyond regulators of myeloid cell activity, the myeloid-derived cytokine network controlled by type I interferons (IFN-α/β, IFN) is of particular importance, serving as a central determinant bridging both innate and adaptive immunity. Here we report that TTYH2 potently restrains NF-κB/IRF signaling and the production of type I interferons. RNA-seq of DMXAA-stimulated Ttyh2 wildtype and knockout mice peritoneal macrophages revealed striking upregulation of type I IFN-stimulated genes, NF-κB regulators, cytokines/chemokines, antigen-presentation genes, costimulatory molecules, and adhesion/integrin signaling.2026/09/09GSE307668GSM9229060GSM9229062GSM9229061GSM9229055GSM9229057GSM9229056GSM9229059GSM922905834290307668Mus musculus