GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE307nnn/GSE307906/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE307906GEOGSEfalseEffect of Ttyh2 Knockout on Tumor Growth Control [scRNA-Seq]We employed single-cell RNA sequencing (scRNA-seq) using the 10x Genomics platform to investigate the role of Ttyh2 in tumor growth control. Ttyh2 knockout (KO) mice exhibited impaired tumor growth. In wild-type (WT) mice, Ttyh2 expression was enriched in Cd206⁺ tumor-associated macrophages (TAMs) and a subset of dendritic cells (DCs). In Ttyh2 KO tumors, the Nos2⁺/Cd206⁺ TAM ratio was elevated, accompanied by a compensatory expansion of monocytes. Pathway analysis revealed upregulation of type I interferon and NF-κB signaling signatures in both TAM subsets and cDC1 cells. Additionally, Ttyh2 KO tumors displayed increased infiltration of CD8⁺ T cells and a reduction in regulatory T cells (Tregs). These findings suggest that Ttyh2 deficiency remodels both the myeloid and lymphoid compartments toward a pro-inflammatory, antitumor immune state.2026/09/09GSE307906GSM9233788GSM923378934290307906Mus musculus