{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE307nnn/GSE307945/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE307945"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Caspase-4 transgenic mice exhibit cytoplasmic TDP-43 accumulation and age-dependent neuropathology","description":"TAR DNA-binding protein (TDP-43) is a multifunctional protein that binds DNA and RNA within the nucleus. However, in human brains affected by Amyotrophic Lateral Sclerosis (ALS) or other pathological conditions, TDP-43 is often mislocalized in the cytoplasm, forming cytoplasmic inclusions. Existing TDP-43 transgenic mouse models have generally failed to exhibit significant cytoplasmic accumulation and loss of nuclear TDP-43, limiting the study of cytoplasmic TDP-43 pathology. In the current study, we developed a transgenic mouse model that expresses the human CASP4 and replicates the cytoplasmic mislocalization of endogenous TDP-43 and motor dysfunction in an age-dependent manner.","dates":{"publication":"2026/05/08"},"accession":"GSE307945","cross_references":{"GSM":["GSM9234451","GSM9234450","GSM9234453","GSM9234452","GSM9234448","GSM9234447","GSM9234449","GSM9234455","GSM9234444","GSM9234454","GSM9234446","GSM9234445"],"GPL":["28330"],"GSE":["307945"],"taxon":["Mus musculus"]}}