GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE307nnn/GSE307945/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE307945GEOGSEfalseCaspase-4 transgenic mice exhibit cytoplasmic TDP-43 accumulation and age-dependent neuropathologyTAR DNA-binding protein (TDP-43) is a multifunctional protein that binds DNA and RNA within the nucleus. However, in human brains affected by Amyotrophic Lateral Sclerosis (ALS) or other pathological conditions, TDP-43 is often mislocalized in the cytoplasm, forming cytoplasmic inclusions. Existing TDP-43 transgenic mouse models have generally failed to exhibit significant cytoplasmic accumulation and loss of nuclear TDP-43, limiting the study of cytoplasmic TDP-43 pathology. In the current study, we developed a transgenic mouse model that expresses the human CASP4 and replicates the cytoplasmic mislocalization of endogenous TDP-43 and motor dysfunction in an age-dependent manner.2026/05/08GSE307945GSM9234451GSM9234450GSM9234453GSM9234452GSM9234448GSM9234447GSM9234449GSM9234455GSM9234444GSM9234454GSM9234446GSM923444528330307945Mus musculus