{"database":"GEO","file_versions":[],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":[" Other","Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE307970"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"A Unique Pediatric Activated T-cell Acute Liver Failure Endotype Characterized by Perforin and Interferon Gamma Expressing Circulating CD8 Tissue Resident Memory T-cells.","description":"Activated T-cell Pediatric Acute Liver Failure (TC-PALF) is the most common cause of non-acetaminophen PALF with poor transplant-free survival. Livers in TC-PALF are infiltrated by effector cytotoxic T lymphocytes with markers of tissue-resident memory function (CD8 Trm) and an interferon gamma (IFNg) transcriptional signature. The PALF-Immune Response Network (PALF-IRN) and the prospective TReatment for ImmUne Mediated PathopHysiology (TRIUMPH) clinical trial (NCT04862221) aim to characterize the TC-PALF immune pathology and utility of T-cell directed therapy to improve transplant free survival.","dates":{"publication":"2026/03/31"},"accession":"GSE307970","cross_references":{"GSM":["GSM9234737","GSM9234729","GSM9234728","GSM9234734","GSM9234733","GSM9234736","GSM9234735","GSM9234730","GSM9234732","GSM9234731"],"GPL":["24676"],"GSE":["307970"],"taxon":["Homo sapiens"]}}