GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE307nnn/GSE307970/primaryOK200TranscriptomicsHomo sapiens OtherExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE307970GEOGSEfalseA Unique Pediatric Activated T-cell Acute Liver Failure Endotype Characterized by Perforin and Interferon Gamma Expressing Circulating CD8 Tissue Resident Memory T-cells.Activated T-cell Pediatric Acute Liver Failure (TC-PALF) is the most common cause of non-acetaminophen PALF with poor transplant-free survival. Livers in TC-PALF are infiltrated by effector cytotoxic T lymphocytes with markers of tissue-resident memory function (CD8 Trm) and an interferon gamma (IFNg) transcriptional signature. The PALF-Immune Response Network (PALF-IRN) and the prospective TReatment for ImmUne Mediated PathopHysiology (TRIUMPH) clinical trial (NCT04862221) aim to characterize the TC-PALF immune pathology and utility of T-cell directed therapy to improve transplant free survival.2026/03/31GSE307970GSM9234737GSM9234729GSM9234728GSM9234734GSM9234733GSM9234736GSM9234735GSM9234730GSM9234732GSM923473124676307970Homo sapiens