{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE308nnn/GSE308086/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomics"],"species":["Canis lupus familiaris"],"gds_type":["Non-coding RNA profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE308086"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Altered expression profile of miRNAs in canine inguinal testes","description":"Cryptorchidism is a major disorder of sex development (DSD) in dogs, with a complex, polygenic background. It is known that in canine undescended testes expression of protein coding genes is massively up- or down-regulated and it is associated with certain epigenetic modifications. In the present study we aimed to compare expression profile of small non-coding RNAs (sncRNAs) in undescended (UD) and descended (D) testes. Undescended (UD) and descended (D) testes of unilateral, inguinal cryptorchid dogs (n=9), as well as scrotal testes of control dogs (C, n=8) were analyzed by small non-coding RNA sequencing (sncRNA-seq) approach. Comparison of UD and D testes revealed 224 differentially expressed miRNA (DEGs), with 118 meeting the criteria of FDR < 0.05 and |log2FC| > 1.5 (8 up- and 110 downregulated). Similarly, comparison of UD and C testes identified 200 DEGs, with 102 meeting the same criteria (9 up- and 93 downregulated).","dates":{"publication":"2026/06/08"},"accession":"GSE308086","cross_references":{"GSM":["GSM9237686","GSM9237687","GSM9237684","GSM9237685","GSM9237682","GSM9237683","GSM9237680","GSM9237681","GSM9237688","GSM9237689","GSM9237690","GSM9237697","GSM9237675","GSM9237676","GSM9237673","GSM9237695","GSM9237696","GSM9237674","GSM9237693","GSM9237694","GSM9237672","GSM9237691","GSM9237692","GSM9237679","GSM9237677","GSM9237678"],"GPL":["25760"],"GSE":["308086"],"taxon":["Canis lupus familiaris"]}}