GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE308nnn/GSE308086/primaryOK200GenomicsCanis lupus familiarisNon-coding RNA profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE308086GEOGSEfalseAltered expression profile of miRNAs in canine inguinal testesCryptorchidism is a major disorder of sex development (DSD) in dogs, with a complex, polygenic background. It is known that in canine undescended testes expression of protein coding genes is massively up- or down-regulated and it is associated with certain epigenetic modifications. In the present study we aimed to compare expression profile of small non-coding RNAs (sncRNAs) in undescended (UD) and descended (D) testes. Undescended (UD) and descended (D) testes of unilateral, inguinal cryptorchid dogs (n=9), as well as scrotal testes of control dogs (C, n=8) were analyzed by small non-coding RNA sequencing (sncRNA-seq) approach. Comparison of UD and D testes revealed 224 differentially expressed miRNA (DEGs), with 118 meeting the criteria of FDR < 0.05 and |log2FC| > 1.5 (8 up- and 110 downregulated). Similarly, comparison of UD and C testes identified 200 DEGs, with 102 meeting the same criteria (9 up- and 93 downregulated).2026/06/08GSE308086GSM9237686GSM9237687GSM9237684GSM9237685GSM9237682GSM9237683GSM9237680GSM9237681GSM9237688GSM9237689GSM9237690GSM9237697GSM9237675GSM9237676GSM9237673GSM9237695GSM9237696GSM9237674GSM9237693GSM9237694GSM9237672GSM9237691GSM9237692GSM9237679GSM9237677GSM923767825760308086Canis lupus familiaris