{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE308nnn/GSE308087/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE308087"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"RNA sequencing and bioinformatics analysis of blood from patients with cortical cataract","description":"This dataset contains raw and processed transcriptomic data derived from peripheral blood mononuclear cells (PBMCs) of patients with age-related cataract (ARC) and matched healthy control individuals. The study aimed to identify systemic gene expression signatures associated with ARC pathogenesis. A total of 6 participants were enrolled in this study, including 3 ARC patients and 3 age- and gender-matched healthy controls.Total RNA was extracted, and library construction was performed using the Illumina TruSeq Stranded mRNA LT Sample Prep Kit. Sequencing was carried out on the Illumina NovaSeq 6000]platform with a 150-bppaired-end strategy. Preliminary bioinformatic analysis revealed 311 increased DEGs and 268 decreased DEGs between ARC patients and refractive cataract patients (|log2FC| > 2and adjusted p-value < 0.05. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses of these DEGs highlighted significant alterations in several biological processes and pathways.This dataset provides a resource for understanding the potential role of systemic factors and immune responses in ARC development, and may facilitate the discovery of novel biomarkers for this common ocular disease.","dates":{"publication":"2026/05/15"},"accession":"GSE308087","cross_references":{"GSM":["GSM9237698","GSM9237703","GSM9237701","GSM9237702","GSM9237699","GSM9237700"],"GPL":["9052"],"GSE":["308087"],"taxon":["Homo sapiens"],"PMID":["[41888716]"]}}