{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE308nnn/GSE308110/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE308110"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptomic profiling of brain tissues from HIV-1 gp120 transgenic mice reveals insights into neuropathogenesis","description":"Despite tremendous progress with antiretroviral therapy, HIV-associated neurocognitive disorders (HAND) remain prevalent, underscoring the need for effective treatments. Sustained immune activation induced by the HIV-1 glycoprotein gp120 is a proposed mechanism leading to neuronal damage in the central nervous system (CNS). To investigate the gp120-mediated transcriptional changes underlying neuropathogenesis, we performed RNA-sequencing (RNA-seq) analysis on brain tissue samples from HIV-1 gp120 transgenic mice and wild-type (WT) control mice to identify differentially expressed genes (DEGs) in the gp120-expressing brains compared to controls.","dates":{"publication":"2026/04/08"},"accession":"GSE308110","cross_references":{"GSM":["GSM9238006","GSM9238015","GSM9238014","GSM9238013","GSM9238012","GSM9238011","GSM9238010","GSM9238009","GSM9238008","GSM9238007"],"GPL":["24247"],"GSE":["308110"],"taxon":["Mus musculus"]}}