GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE308nnn/GSE308110/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE308110GEOGSEfalseTranscriptomic profiling of brain tissues from HIV-1 gp120 transgenic mice reveals insights into neuropathogenesisDespite tremendous progress with antiretroviral therapy, HIV-associated neurocognitive disorders (HAND) remain prevalent, underscoring the need for effective treatments. Sustained immune activation induced by the HIV-1 glycoprotein gp120 is a proposed mechanism leading to neuronal damage in the central nervous system (CNS). To investigate the gp120-mediated transcriptional changes underlying neuropathogenesis, we performed RNA-sequencing (RNA-seq) analysis on brain tissue samples from HIV-1 gp120 transgenic mice and wild-type (WT) control mice to identify differentially expressed genes (DEGs) in the gp120-expressing brains compared to controls.2026/04/08GSE308110GSM9238006GSM9238015GSM9238014GSM9238013GSM9238012GSM9238011GSM9238010GSM9238009GSM9238008GSM923800724247308110Mus musculus