{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE308nnn/GSE308330/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomics"],"species":["Homo sapiens"],"gds_type":["Genome binding/occupancy profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE308330"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Super-enhancer formation in scirrhous gastric cancer-associated fibroblasts, and its presence in fibroblasts in non-cancerous tissues (1)","description":"Scirrhous gastric cancer has aggressive clinical courses and is characterized by dominating cancer-associated fibroblasts (CAFs). We here aimed to explore the molecular basis for scirrhous CAFs and their origin. Scirrhous CAFs had heavily acetylated super-enhancers, and therapeutic targeting of super-enhancers by a BET bromodomain inhibitor, mivebresib, markedly decreased their migration-promoting activity.","dates":{"publication":"2026/06/10"},"accession":"GSE308330","cross_references":{"GSM":["GSM9242340","GSM9242332","GSM9242333","GSM9242341","GSM9242330","GSM9242331","GSM9242342","GSM9242336","GSM9242337","GSM9242334","GSM9242335","GSM9242329","GSM9242338","GSM9242327","GSM9242328","GSM9242339"],"GPL":["30173"],"GSE":["308330"],"taxon":["Homo sapiens"],"PMID":["[42070972]"]}}