GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE308nnn/GSE308330/primaryOK200GenomicsHomo sapiensGenome binding/occupancy profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE308330GEOGSEfalseSuper-enhancer formation in scirrhous gastric cancer-associated fibroblasts, and its presence in fibroblasts in non-cancerous tissues (1)Scirrhous gastric cancer has aggressive clinical courses and is characterized by dominating cancer-associated fibroblasts (CAFs). We here aimed to explore the molecular basis for scirrhous CAFs and their origin. Scirrhous CAFs had heavily acetylated super-enhancers, and therapeutic targeting of super-enhancers by a BET bromodomain inhibitor, mivebresib, markedly decreased their migration-promoting activity.2026/06/10GSE308330GSM9242340GSM9242332GSM9242333GSM9242341GSM9242330GSM9242331GSM9242342GSM9242336GSM9242337GSM9242334GSM9242335GSM9242329GSM9242338GSM9242327GSM9242328GSM924233930173308330Homo sapiens[42070972]