{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE308nnn/GSE308431/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Rattus norvegicus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE308431"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"RNA-seq analysis of spiral ganglion neurons treated with cisplatin and dimethyl fumarate to elucidate otoprotective mechanisms","description":"This study aims to elucidate the potential protective mechanisms of dimethyl fumarate (DMF) against cisplatin-induced ototoxicity at the transcriptomic level. Spiral ganglion neurons (SGNs) were divided into two treatment groups: cisplatin alone and cisplatin combined with DMF. Gene expression profiling was performed using high-throughput RNA-sequencing. Differential expression analysis identified a set of significantly upregulated and downregulated genes in the DMF combination group compared to the cisplatin-only group. Pathway enrichment analysis highlighted significant alterations in autophagy and mitophagy pathways, suggesting that DMF may alleviate cisplatin-induced damage by modulating these processes in SGNs. This dataset provides the raw sequencing reads (FASTQ) and gene count matrix, serving as a valuable resource for investigating drug-induced ototoxicity and protective therapeutic strategies.","dates":{"publication":"2026/09/15"},"accession":"GSE308431","cross_references":{"GSM":["GSM9245348","GSM9245349","GSM9245344","GSM9245345","GSM9245346","GSM9245347"],"GPL":["25947"],"GSE":["308431"],"taxon":["Rattus norvegicus"]}}