{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE308nnn/GSE308503/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":[" Mus musculus","Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE308503"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"The transcriptomic profile of the naïve or CpG-stimulated Rfx7-deficient mouse Follicular B cells and RFX7-transfected lymphoma human cell line U-2932","description":"PART 1) Alterations of the transcription factor RFX7 have been reported in different B-cell malignancies. We therefore set out to study the role of RFX7 in B cell activation. So we performed bulk RNA-seq on sorted wild-type or Rfx7-deficient follicular B cells, either naive or activated with CpG. PART 2) RFX7 frameshift and non-sense mutations have been reported in different B-cell malignancies. We therefore set out to study the role of selected truncations in a human lymphoma cell line. We performed bulk RNA-seq on sorted U-2932 cells transfected with different RFX7 encoding constructs.","dates":{"publication":"2026/04/15"},"accession":"GSE308503","cross_references":{"GSM":["GSM9375880","GSM9246877","GSM9375884","GSM9375883","GSM9246878","GSM9375882","GSM9246879","GSM9375881","GSM9246874","GSM9375887","GSM9375886","GSM9246875","GSM9375885","GSM9246876","GSM9375879","GSM9375878","GSM9246880","GSM9246881","GSM9246882","GSM9246883","GSM9375873","GSM9375872","GSM9375871","GSM9375870","GSM9246884","GSM9375877","GSM9375876","GSM9375875","GSM9375874"],"GPL":["30173","30172"],"GSE":["308503"],"taxon":[" Mus musculus","Homo sapiens"]}}