{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE308nnn/GSE308509/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":[" Other","Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE308509"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"MAIT cells at different developmental stages egress the thymus to colonize specific tissues and sense increases in peripheral ligands","description":"MAIT but not iNKT cells can be selected by thymic epithelial cells, while both require CD4+CD8+ thymocytes for maturation. MAIT and iNKT cells have similar developmental dynamics and thymic-residency properties but proliferate at different developmental stages.MAIT cells exit the thymus in an S1PR-dependent manner at different maturation stages to colonize specific peripheral organs.PLZF+Tbet-RORgt- MAIT cells preferentially colonize the intestine in a CCR9-dependent manner.Thymic output contributes to peripheral MAIT and iNKT cell numbers at steady state. Thymic MAIT17 cells are activated and expand in colitis and after bacterial exposure.","dates":{"publication":"2026/04/13"},"accession":"GSE308509","cross_references":{"GSM":["GSM9247074","GSM9247075","GSM9247076","GSM9247077","GSM9247073"],"GPL":["24247","16417"],"GSE":["308509"],"taxon":["Mus musculus"]}}