{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE308nnn/GSE308678/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomics"],"species":["Mus musculus"],"gds_type":["Genome binding/occupancy profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE308678"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"​​Lactate Modulates Transcriptional Regulation through H3K14ac​","description":"Lactate functions as an epigenetic modulator by inhibiting histone deacetylases (HDACs), leading to increased global histone acetylation and altered gene expression. Performing H3K14ac CUT&TAG in lactate-treated cells enables precise genome-wide mapping of lactate-driven epigenetic changes, specifically revealing hyperacetylated promoters and enhancers linked to transcriptional activation.","dates":{"publication":"2026/08/22"},"accession":"GSE308678","cross_references":{"GSM":["GSM9251215","GSM9251216","GSM9251217","GSM9251210","GSM9251211","GSM9251212","GSM9251213"],"GPL":["34328"],"GSE":["308678"],"taxon":["Mus musculus"]}}