{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE308nnn/GSE308795/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE308795"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Synergistic blockade of cyclophilin A and pathogenic immunity minimizes pregnancy-context pathologies in response to the Zika virus","description":"Zika virus (ZIKV) jeopardizes fetal health through both vertical transmission and placental disorders, while the regulatory mechanisms and therapeutic opportunities remain elusive. Here, we reveal cyclophilin A (CypA) as a critical host factor necessary for placental ZIKV replication, functioning independently of its isomerase activity and calcineurin-dependent pathway.","dates":{"publication":"2026/04/22"},"accession":"GSE308795","cross_references":{"GSM":["GSM9253290","GSM9253292","GSM9253291","GSM9253294","GSM9253293","GSM9253287","GSM9253286","GSM9253289","GSM9253288"],"GPL":["23479"],"GSE":["308795"],"taxon":["Mus musculus"]}}