{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE309nnn/GSE309283/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomics"],"species":["Escherichia coli"],"gds_type":["Non-coding RNA profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE309283"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Changes in tRNA wobble modifications under a norepinephrine gradient coincide with codon-biased translation and induction of virulence in EHEC O157:H7","description":"The goal of this study was to investigate how Enterohemorrhagic Escherichia coli O157:H7 (EHEC) strain EDL933 remodels its tRNA pool in response to the catecholamine hormone norepinephrine, a host-derived cue that stimulates virulence in this pathogen. Here, we performed Absolute Quantitative RNA-sequencing (AQRNA-seq) to measure levels of tRNA isoacceptors in EHEC samples exposed to 0, 25, and 50 micromolar norepinephrine.","dates":{"publication":"2026/04/17"},"accession":"GSE309283","cross_references":{"GSM":["GSM9264359","GSM9264367","GSM9264366","GSM9264365","GSM9264364","GSM9264363","GSM9264362","GSM9264361","GSM9264360"],"GPL":["16085"],"GSE":["309283"],"taxon":["Escherichia coli"]}}