{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE309nnn/GSE309395/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE309395"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Extracellular vesicle-derived circRNA profiles from cART suppressed pregnant women living with HIV identifies interactome networks key to inflammation and viral latency","description":"Pregnant people living with HIV (PLWH) experience a disparate risk of chronic non-AIDS-related morbidities (NAMs) during pregnancy compared to people without HIV infection. Extracellular vesicles (EV) are fundamental to both HIV pathogenesis and maternal-placental-fetal systemic intercellular networking. However, there is limited research addressing the intersection of EV cargo and HIV during pregnancy. In this study, plasma-derived EV small RNA (smRNA) in pregnant PLWH as compared to pregnant people living without HIV (PLWoH) was examined through low-input RNA sequencing (Illumina PE150). Differential expression analysis identified significant alterations of EV circRNA levels for pregnant PLWH as compared to pregnant PLWoH. Novel interactome networks (circRNA-miRNA-gene and circRNA-protein) were generated from these differentially expressed EV circRNAs. Gene set enrichment analysis revealed physiological pathways influential to HIV reservoir establishment, latency, replication, immune activation, immunosenescence, as well as maternal-placental-fetal immune cross talk. These findings suggest that EV circRNA-mediated regulatory mechanisms may contribute to HIV persistence, inflammation, and immune modulation in pregnancy.","dates":{"publication":"2026/06/03"},"accession":"GSE309395","cross_references":{"GSM":["GSM9266799","GSM9266810","GSM9266800","GSM9266811","GSM9266812","GSM9266801","GSM9266802","GSM9266813","GSM9266803","GSM9266814","GSM9266815","GSM9266804","GSM9266805","GSM9266816","GSM9266806","GSM9266807","GSM9266808","GSM9266809"],"GPL":["20795"],"GSE":["309395"],"taxon":["Homo sapiens"],"PMID":["[42231329]"]}}