{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE309nnn/GSE309461/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE309461"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Bulk RNA sequencing of liver NK cells and ILC1s from T-bet WT vs. inducible Ncr1-T-bet Δ/Δ mice","description":"The role of the T-box transcription factors T-bet and Eomes in innate lymphoid cells (ILCs) beyond their development is not well understood. We generated an inducible, NKp46 (Ncr1)-specific T-bet floxed knock-out mouse (Ncr1-T-betΔ/Δ) model. Bulk RNA sequencing of liver NK cells after tamoxifen treatment from T-bet WT (NKp46-CreERT2 x T-bet fl/fl) vs. Ncr1-T-bet Δ/Δ (NKp46-CreERT2 x T-bet fl/fl) mice had minimal transcriptional changes, whereas T-bet-deficient ILC1 exhibited significant gene expression changes. This sequencing data along with their rapid loss in vivo in Ncr1-T-betΔ/Δ mice reveal the requirement for continuous T-bet expression in liver ILC1.","dates":{"publication":"2026/04/06"},"accession":"GSE309461","cross_references":{"GSM":["GSM9267730","GSM9267721","GSM9267720","GSM9267731","GSM9267723","GSM9267722","GSM9267725","GSM9267724","GSM9267727","GSM9267716","GSM9267726","GSM9267729","GSM9267718","GSM9267717","GSM9267728","GSM9267719"],"GPL":["34290"],"GSE":["309461"],"taxon":["Mus musculus"]}}