GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE309nnn/GSE309461/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE309461GEOGSEfalseBulk RNA sequencing of liver NK cells and ILC1s from T-bet WT vs. inducible Ncr1-T-bet Δ/Δ miceThe role of the T-box transcription factors T-bet and Eomes in innate lymphoid cells (ILCs) beyond their development is not well understood. We generated an inducible, NKp46 (Ncr1)-specific T-bet floxed knock-out mouse (Ncr1-T-betΔ/Δ) model. Bulk RNA sequencing of liver NK cells after tamoxifen treatment from T-bet WT (NKp46-CreERT2 x T-bet fl/fl) vs. Ncr1-T-bet Δ/Δ (NKp46-CreERT2 x T-bet fl/fl) mice had minimal transcriptional changes, whereas T-bet-deficient ILC1 exhibited significant gene expression changes. This sequencing data along with their rapid loss in vivo in Ncr1-T-betΔ/Δ mice reveal the requirement for continuous T-bet expression in liver ILC1.2026/04/06GSE309461GSM9267730GSM9267721GSM9267720GSM9267731GSM9267723GSM9267722GSM9267725GSM9267724GSM9267727GSM9267716GSM9267726GSM9267729GSM9267718GSM9267717GSM9267728GSM926771934290309461Mus musculus