{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE309nnn/GSE309834/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":[" Genome binding/occupancy profiling by high throughput sequencing","Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE309834"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Massively multiplex multi-modal chemical screens at single-cell resolution with DOGMA-plex","description":"We present DOGMA-plex, a novel cellular barcoding systems that enable multiplexed analysis of multiple independent samples within a single experiment through a combination of viral barcodes and antibody-based plate-barcodes. Using this platform, we successfully profiled around 1,200 drug-dose responses across 475 surface proteins, chromatin accessibility, and the whole transcriptome in human treated with around 300 different chromatin inhibitors, demonstrating the method's ability to capture multi-modal cellular responses to chemical perturbations.","dates":{"publication":"2026/04/14"},"accession":"GSE309834","cross_references":{"GSM":["GSM9282849","GSM9282848","GSM9282843","GSM9282842","GSM9282841","GSM9282840","GSM9282847","GSM9282846","GSM9282845","GSM9282844","GSM9282850","GSM9282859","GSM9282854","GSM9282853","GSM9282852","GSM9282851","GSM9282858","GSM9282857","GSM9282856","GSM9282855","GSM9282861","GSM9282860","GSM9282906","GSM9282905","GSM9282904","GSM9282903","GSM9282909","GSM9282908","GSM9282907","GSM9282865","GSM9282864","GSM9282863","GSM9282862","GSM9282869","GSM9282902","GSM9282901","GSM9282868","GSM9282900","GSM9282867","GSM9282866","GSM9282872","GSM9282871","GSM9282870","GSM9282917","GSM9282916","GSM9282915","GSM9282914","GSM9282919","GSM9282918","GSM9282876","GSM9282875","GSM9282874","GSM9282873","GSM9282913","GSM9282912","GSM9282879","GSM9282878","GSM9282911","GSM9282877","GSM9282910","GSM9282883","GSM9282882","GSM9282881","GSM9282880","GSM9282807","GSM9282928","GSM9282806","GSM9282927","GSM9282926","GSM9282805","GSM9282804","GSM9282925","GSM9282809","GSM9282929","GSM9282808","GSM9282920","GSM9282887","GSM9282886","GSM9282885","GSM9282884","GSM9282803","GSM9282924","GSM9282923","GSM9282802","GSM9282889","GSM9282801","GSM9282922","GSM9282800","GSM9282921","GSM9282888","GSM9282890","GSM9282894","GSM9282893","GSM9282892","GSM9282891","GSM9282818","GSM9282817","GSM9282816","GSM9282815","GSM9282936","GSM9282819","GSM9282898","GSM9282810","GSM9282931","GSM9282897","GSM9282930","GSM9282896","GSM9282895","GSM9282814","GSM9282935","GSM9282813","GSM9282934","GSM9282812","GSM9282933","GSM9282932","GSM9282899","GSM9282811","GSM9282829","GSM9282828","GSM9282827","GSM9282826","GSM9282821","GSM9282820","GSM9282825","GSM9282824","GSM9282823","GSM9282822","GSM9282839","GSM9282838","GSM9282837","GSM9282832","GSM9282799","GSM9282798","GSM9282831","GSM9282797","GSM9282830","GSM9282836","GSM9282835","GSM9282834","GSM9282833"],"GPL":["24676"],"GSE":["309834"],"taxon":["Homo sapiens"]}}