GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE309nnn/GSE309834/primaryOK200TranscriptomicsHomo sapiens Genome binding/occupancy profiling by high throughput sequencingExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE309834GEOGSEfalseMassively multiplex multi-modal chemical screens at single-cell resolution with DOGMA-plexWe present DOGMA-plex, a novel cellular barcoding systems that enable multiplexed analysis of multiple independent samples within a single experiment through a combination of viral barcodes and antibody-based plate-barcodes. Using this platform, we successfully profiled around 1,200 drug-dose responses across 475 surface proteins, chromatin accessibility, and the whole transcriptome in human treated with around 300 different chromatin inhibitors, demonstrating the method's ability to capture multi-modal cellular responses to chemical perturbations.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 sapiens