{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE309nnn/GSE309927/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE309927"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"RNAseq analysis of transcriptome changes induced by ALDH1B1 inhibition in Panc 10.05 cells","description":"ALDH1B1, a mitochondrial aldehyde dehydrogenase, is required for the survival of stem-like colorectal and pancreatic cancer cells and a promising drug target. We have developed an optimized ALDH1B1 selective inhibitor, IGUANA-5 (IG5) and have characterized the transcriptome changes induced by IG5 in a pancreatic cancer cell line, Panc 10.05. Genes induced by IG5 in Panc 10.05 cells include those related to mitochondrial respiration and cholesterol biosynthesis.","dates":{"publication":"2026/09/24"},"accession":"GSE309927","cross_references":{"GSM":["GSM9284892","GSM9284891","GSM9284890","GSM9284896","GSM9284895","GSM9284894","GSM9284893","GSM9284897"],"GPL":["24676"],"GSE":["309927"],"taxon":["Homo sapiens"]}}