GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE309nnn/GSE309936/primaryOK200TranscriptomicsMus musculus OtherExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE309936GEOGSEfalsemRNA expression profile of OVA-specific Th2 cells from cLNs of mice injected with or without OVA-specific IgE after nasal OVA challengeTo elucidate the role of systemic antigen-specific IgE in the local activation of Th2 cells during allergic rhinitis (AR), we employed an adoptive transfer-based AR mouse model. Mice were adoptively sensitized with OVA-specific IgE (OVA-IgE) and/or in vitro-differentiated OVA-specific Th2 (OVA-Th2) cells, followed by intranasal OVA challenge. Single-cell RNA sequencing was performed to analyze the mRNA expression profiles of Th2 cells isolated from cervical lymph nodes of mice injected with or without OVA-specific IgE. Freshly cultured OVA-Th2 cells were included as controls.2026/05/24GSE309936GSM9284994GSM928499528457309936Mus musculus