{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE310nnn/GSE310014/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomics"],"species":["Mus musculus"],"gds_type":["Genome binding/occupancy profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE310014"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"MBD3 regulates thymic Treg precursor cell development by modulating CD25 expression [ChIP-seq]","description":"ChIP-seq was performed in wild-type (WT) thymocytes to profile MBD3 occupancy and histone modifications, including H3K27ac and H3K4me1. These data reveal direct binding of MBD3 to Treg-specific regulatory regions and co-localization with activating histone marks. In Mbd3 conditional knockout (CKO) thymocytes, these regulatory regions exhibit altered chromatin modifications, correlating with impaired thymic Treg differentiation. These ChIP-seq datasets provide a multi-omic view of how MBD3 binding and associated histone modifications contribute to thymic Treg lineage specification.","dates":{"publication":"2026/09/29"},"accession":"GSE310014","cross_references":{"GSM":["GSM9286488","GSM9286477","GSM9286478","GSM9286479","GSM9286484","GSM9286485","GSM9286486","GSM9286487","GSM9286476","GSM9286480","GSM9286481","GSM9286482","GSM9286483"],"GPL":["25723","34290"],"GSE":["310014"],"taxon":["Mus musculus"]}}