GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE310nnn/GSE310014/primaryOK200GenomicsMus musculusGenome binding/occupancy profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE310014GEOGSEfalseMBD3 regulates thymic Treg precursor cell development by modulating CD25 expression [ChIP-seq]ChIP-seq was performed in wild-type (WT) thymocytes to profile MBD3 occupancy and histone modifications, including H3K27ac and H3K4me1. These data reveal direct binding of MBD3 to Treg-specific regulatory regions and co-localization with activating histone marks. In Mbd3 conditional knockout (CKO) thymocytes, these regulatory regions exhibit altered chromatin modifications, correlating with impaired thymic Treg differentiation. These ChIP-seq datasets provide a multi-omic view of how MBD3 binding and associated histone modifications contribute to thymic Treg lineage specification.2026/09/29GSE310014GSM9286488GSM9286477GSM9286478GSM9286479GSM9286484GSM9286485GSM9286486GSM9286487GSM9286476GSM9286480GSM9286481GSM9286482GSM92864832572334290310014Mus musculus