{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE310nnn/GSE310016/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomics"],"species":["Mus musculus"],"gds_type":["Genome binding/occupancy profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE310016"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"MBD3 regulates thymic Treg precursor cell development by modulating CD25 expression [ATAC-seq]","description":"ATAC-seq was performed on thymic T cell subsets, focusing on immature CD4 single-positive (ImCD4SP) cells, as well as pre-tTreg and mature tTreg cells, from wild-type (WT) and Mbd3 conditional knockout (CKO) mice. Chromatin accessibility changes were most pronounced in the ImCD4SP stage, consistent with RNA-seq data indicating that transcriptional differences arise early, likely reflecting altered responses to stimulation preceding pre-tTreg specification. Loss of MBD3 altered accessibility at regulatory regions of Treg-associated genes. These ATAC-seq datasets offer insight into the epigenetic mechanisms by which MBD3 shapes early thymic Treg development.","dates":{"publication":"2026/09/29"},"accession":"GSE310016","cross_references":{"GSM":["GSM9286510","GSM9286511","GSM9286512","GSM9286513","GSM9286507","GSM9286508","GSM9286509","GSM9286514","GSM9286515","GSM9286516","GSM9286506","GSM9286517"],"GPL":["34290"],"GSE":["310016"],"taxon":["Mus musculus"]}}