{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE310nnn/GSE310055/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE310055"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Identification and enrichment of human retinal organoid-derived red/green cone-competent precursors with enhanced axon dynamics","description":"Cell replacement therapies aimed at restoring central vision require a source of red/green (long/medium wavelength, or L/M) cone photoreceptors with integrative properties. Toward this end, we developed a means to identify early L/M cone precursors from human pluripotent stem cell-derived retinal organoids (ROs) by linking tdTomato to the endogenous THRB2 promoter. Subsequent bulk RNA sequencing of fluorescence-activated cell sorted ROs showed that very early L/M cones were specifically enriched in genes associated with neural development, axon extension guidance, and cell migration.","dates":{"publication":"2026/08/21"},"accession":"GSE310055","cross_references":{"GSM":["GSM9287398","GSM9287387","GSM9287386","GSM9287397","GSM9287389","GSM9287399","GSM9287388","GSM9287383","GSM9287394","GSM9287393","GSM9287382","GSM9287396","GSM9287385","GSM9287384","GSM9287395","GSM9287390","GSM9287381","GSM9287392","GSM9287380","GSM9287391"],"GPL":["24676"],"GSE":["310055"],"taxon":["Homo sapiens"],"PMID":["[42401922]"]}}