GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE310nnn/GSE310055/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE310055GEOGSEfalseIdentification and enrichment of human retinal organoid-derived red/green cone-competent precursors with enhanced axon dynamicsCell replacement therapies aimed at restoring central vision require a source of red/green (long/medium wavelength, or L/M) cone photoreceptors with integrative properties. Toward this end, we developed a means to identify early L/M cone precursors from human pluripotent stem cell-derived retinal organoids (ROs) by linking tdTomato to the endogenous THRB2 promoter. Subsequent bulk RNA sequencing of fluorescence-activated cell sorted ROs showed that very early L/M cones were specifically enriched in genes associated with neural development, axon extension guidance, and cell migration.2026/08/21GSE310055GSM9287398GSM9287387GSM9287386GSM9287397GSM9287389GSM9287399GSM9287388GSM9287383GSM9287394GSM9287393GSM9287382GSM9287396GSM9287385GSM9287384GSM9287395GSM9287390GSM9287381GSM9287392GSM9287380GSM928739124676310055Homo sapiens[42401922]