{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE310nnn/GSE310065/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE310065"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Molecular Mechanism of Oncostatin M-Mediated Bronchopulmonary Dysplasia Induced by Intrauterine Inflammation","description":"Intrauterine inflammation is a key risk factor for bronchopulmonary dysplasia (BPD) in preterm infants, though mechanisms remain unclear. We found that intrauterine inflammation activates fetal pulmonary macrophages, which upregulate Oncostatin M (OSM) via Junb. OSM then induces alveolar epithelial cell senescence through the Atf3-p21 signaling pathway, resulting in developmental lung injury. This study identifies a novel macrophage-OSM-epithelial senescence axis in BPD pathogenesis, offering potential therapeutic targets.","dates":{"publication":"2026/09/16"},"accession":"GSE310065","cross_references":{"GSM":["GSM9287718","GSM9287717","GSM9287719","GSM9287714","GSM9287716","GSM9287715"],"GPL":["24247"],"GSE":["310065"],"taxon":["Mus musculus"]}}