{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE310nnn/GSE310086/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomics"],"species":["Homo sapiens"],"gds_type":["Genome binding/occupancy profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE310086"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Lactate Drives Epigenetic Reprogramming and Activation of Hepatic Stellate Cells via Altering Chromatin Accessibility","description":"Activation of hepatic stellate cells (HSCs) is a central driver of liver fibrosis, and the metabolite lactate has emerged as a potential signaling molecule beyond its role in metabolism. To investigate whether it influences HSC activation through epigenetic mechanisms, we treated human primary HSCs with L-lactate and utilized Assay for Transposase-Accessible Chromatin using sequencing (ATAC-seq) to map genome-wide changes in chromatin accessibility, complemented by assays for gene expression to correlate these changes with the pro-fibrotic activation phenotype.","dates":{"publication":"2026/08/22"},"accession":"GSE310086","cross_references":{"GSM":["GSM9287941","GSM9287940","GSM9287942","GSM9287938","GSM9287937","GSM9287939"],"GPL":["24676"],"GSE":["310086"],"taxon":["Homo sapiens"]}}