GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE310nnn/GSE310090/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE310090GEOGSEfalseThe orally available SIK2/SIK3 inhibitor SK-124 increases bone mass in hypogonadal male miceWe previously described the synthesis and characterization of SK-124, a pharmacologic SIK2/SIK3 inhibitor that increases trabecular bone formation in eugonadal mice. However, the efficacy of this agent in osteoporosis mouse models remains unknown. In this study, we investigated the therapeutic potential of SK-124 in a male hypogonadal bone loss model (orchiectomy, ORX) in BALB/c male mice.Bone RNA-sequencing analysis demonstrated novel pathways associated with increased bone formation in response to SK-124 treatment.2026/03/31GSE310090GSM9287974GSM9287973GSM9287976GSM9287975GSM9287981GSM9287980GSM9287972GSM9287982GSM9287971GSM9287978GSM9287977GSM928797934328310090Mus musculus[41908158]