{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Txt":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE310nnn/GSE310185/suppl/filelist.txt"],"Raw":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE310nnn/GSE310185/suppl/GSE310185_RAW.tar"],"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE310nnn/GSE310185/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomics"],"species":["Mus musculus"],"gds_type":["Genome binding/occupancy profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE310185"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"NMuMG PBRM1 ChIP-seq","description":"Mammalian SWI/SNF or BAF are multi-subunit complexes that regulate cell-type specific gene expression by modulating chromatin accessibility, in coordination with transcription factors and other chromatin regulators. PBRM1 is the complex defining subunit of PBAF class of SWI/SNF complexes. It is mutated in ~40% of clear cell renal cell carcinoma cases but also associated with cancer progression and therapy resistance, indicating context-dependent function. We have previously reported that loss of PBRM1 in normal epithelial cells results in a partial Epithelial-to-Mesenchymal Transition (EMT). In this study, we have utilized epigenomic and transcriptomic approaches to understand the mechanistic role of PBRM1 in EMT-regulated gene expression, and its relationship to genome-wide histone modifications.","dates":{"publication":"2026/06/16"},"accession":"GSE310185","cross_references":{"GSM":["GSM9290724","GSM9290702","GSM9290703","GSM9290725","GSM9290726","GSM9290704","GSM9290727","GSM9290705","GSM9290706","GSM9290728","GSM9290707","GSM9290729","GSM9290708","GSM9290709","GSM9290740","GSM9290741","GSM9290720","GSM9290742","GSM9290743","GSM9290721","GSM9290700","GSM9290744","GSM9290722","GSM9290723","GSM9290701","GSM9290735","GSM9290713","GSM9290714","GSM9290736","GSM9290737","GSM9290715","GSM9290738","GSM9290716","GSM9290717","GSM9290739","GSM9290718","GSM9290719","GSM9290730","GSM9290731","GSM9290698","GSM9290732","GSM9290710","GSM9290699","GSM9290711","GSM9290733","GSM9290734","GSM9290712"],"GPL":["24247"],"GSE":["310185"],"taxon":["Mus musculus"]}}