{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE310nnn/GSE310229/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Rattus norvegicus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE310229"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Identification and validation of central amygdala FGFR1 as a therapeutic target for alcohol use disorder using single nucleus sequencing in rat","description":"Understanding why some individuals are more vulnerable to alcohol addiction is key to developing effective treatments. We used cell-specific transcriptomics to dissect the central amygdala (CeA) of rats that continued drinking alcohol despite punishment—a hallmark of compulsive-like behavior. We found profound transcriptional changes in PKCδ+ neurons, with FGFR1 emerging as a central upstream regulator. Silencing FgfR1 in these neurons significantly reduced compulsive-like alcohol self-administration, positioning FGFR1 signaling as a promising therapeutic target—especially given the availability of FDA-approved inhibitors. We also uncovered major transcriptional shifts in Calcrl+/Drd2+ neurons, suggesting a broader CeA network reorganization that may contribute to compulsive-like self-administration. Together, these findings identify distinct CeA circuits driving addiction vulnerability, and open new avenues for targeted intervention.","dates":{"publication":"2026/07/22"},"accession":"GSE310229","cross_references":{"GSM":["GSM9291780","GSM9291781","GSM9291782","GSM9291772","GSM9291794","GSM9291795","GSM9291773","GSM9291796","GSM9291774","GSM9291775","GSM9291797","GSM9291798","GSM9291776","GSM9291799","GSM9291777","GSM9291778","GSM9291779","GSM9291790","GSM9291791","GSM9291792","GSM9291770","GSM9291793","GSM9291771","GSM9291769","GSM9291802","GSM9291783","GSM9291784","GSM9291785","GSM9291786","GSM9291787","GSM9291788","GSM9291789","GSM9291767","GSM9291800","GSM9291801","GSM9291768"],"GPL":["25947"],"GSE":["310229"],"taxon":["Rattus norvegicus"],"PMID":["[42686758]"]}}