GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE310nnn/GSE310671/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE310671GEOGSEfalseRNA-seq of PRDX6 Knockdown and Control A223 Squamous Cell Carcinoma Cells Treated With HDAC Inhibitor LargazoleThis dataset comprises RNA sequencing data generated from A223 squamous cell carcinoma cells with stable knockdown of PRDX6 or parental control, treated with either DMSO or 100 nM largazole (a class I histone deacetylase inhibitor) for 18 hours. The study investigates the role of PRDX6 in modulating ferroptosis susceptibility and inflammatory responses upon HDAC inhibition. Transcriptomic profiling was performed to evaluate pathway enrichment and gene expression signatures associated with ferroptosis, redox homeostasis, and immune activation. Results demonstrate that PRDX6 knockdown enhances largazole-induced ferroptotic and inflammatory transcriptional programs, implicating PRDX6 as a redox rheostat suppressing immunogenic stress responses in squamous carcinoma.2026/05/01GSE310671GSM9305682GSM9305683GSM9305684GSM9305685GSM9305686GSM9305679GSM9305680GSM930568124247310671Mus musculus