{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE310nnn/GSE310706/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE310706"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Identification of a set of transcriptional regulators involved in the temporal regulation of neuron subtype differentiation [RNA-Seq]","description":"The sequential generation of various types of neurons and glia from neural stem /progenitor cells (NSPCs) during development is a major part to build complex central nervous system. Here, we identify PHF21b, ZFP7 and ZFP57 as crucial factors that regulate the transition from early-born neuron to late-born neuron generation by NSPCs in the developing mouse cortex and ganglionic eminence. Combinatorial overexpression of these three factors in the stage progressed NSPCs generating late-born neurons resulted in prolonged generation of early-born neurons. Conversely, simultaneous knockdown of these genes suppressed generation of early-born neurons.","dates":{"publication":"2026/03/31"},"accession":"GSE310706","cross_references":{"GSM":["GSM9307289","GSM9307300","GSM9307299","GSM9307288","GSM9307302","GSM9307301","GSM9307304","GSM9307303","GSM9307306","GSM9307305","GSM9307307","GSM9307290","GSM9307292","GSM9307291","GSM9307294","GSM9307293","GSM9307285","GSM9307296","GSM9307295","GSM9307287","GSM9307298","GSM9307286","GSM9307297"],"GPL":["24247"],"GSE":["310706"],"taxon":["Mus musculus"]}}