GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE310nnn/GSE310706/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE310706GEOGSEfalseIdentification of a set of transcriptional regulators involved in the temporal regulation of neuron subtype differentiation [RNA-Seq]The sequential generation of various types of neurons and glia from neural stem /progenitor cells (NSPCs) during development is a major part to build complex central nervous system. Here, we identify PHF21b, ZFP7 and ZFP57 as crucial factors that regulate the transition from early-born neuron to late-born neuron generation by NSPCs in the developing mouse cortex and ganglionic eminence. Combinatorial overexpression of these three factors in the stage progressed NSPCs generating late-born neurons resulted in prolonged generation of early-born neurons. Conversely, simultaneous knockdown of these genes suppressed generation of early-born neurons.2026/03/31GSE310706GSM9307289GSM9307300GSM9307299GSM9307288GSM9307302GSM9307301GSM9307304GSM9307303GSM9307306GSM9307305GSM9307307GSM9307290GSM9307292GSM9307291GSM9307294GSM9307293GSM9307285GSM9307296GSM9307295GSM9307287GSM9307298GSM9307286GSM930729724247310706Mus musculus