{"database":"GEO","file_versions":[],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE310741"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Characterizing breast cancer cell biochemical responses to fluid shear in a 3D loading model","description":"Bone is the most common site of breast cancer metastasis—only 12% of patients with skeletal metastases demonstrate a 5-year survival rate after diagnosis. Bone metastasis is characterized by a vicious cycle, where tumor-secreted factors results in increased bone turnover that often favors net bone loss. Mechanical loading, typically a bone anabolic and osteoprotective stimulus, has been shown to have positive effects on osteolytic lesions in vivo. However, the underlying mechanisms are still under investigation. Full characterization of the tumor-secreted factors that influence cancer-induced osteolysis will improve our understanding of atypical bone remodeling and mechanoresponses in tumor-induced bone disease.","dates":{"publication":"2026/05/25"},"accession":"GSE310741","cross_references":{"GSM":["GSM9307810","GSM9307812","GSM9307811","GSM9307813","GSM9307809","GSM9307808"],"GPL":["34281"],"GSE":["310741"],"taxon":["Homo sapiens"]}}