GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE310nnn/GSE310741/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE310741GEOGSEfalseCharacterizing breast cancer cell biochemical responses to fluid shear in a 3D loading modelBone is the most common site of breast cancer metastasis—only 12% of patients with skeletal metastases demonstrate a 5-year survival rate after diagnosis. Bone metastasis is characterized by a vicious cycle, where tumor-secreted factors results in increased bone turnover that often favors net bone loss. Mechanical loading, typically a bone anabolic and osteoprotective stimulus, has been shown to have positive effects on osteolytic lesions in vivo. However, the underlying mechanisms are still under investigation. Full characterization of the tumor-secreted factors that influence cancer-induced osteolysis will improve our understanding of atypical bone remodeling and mechanoresponses in tumor-induced bone disease.2026/05/25GSE310741GSM9307810GSM9307812GSM9307811GSM9307813GSM9307809GSM930780834281310741Homo sapiens