{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE310nnn/GSE310884/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Methylation profiling"],"species":["Homo sapiens"],"gds_type":["Methylation profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE310884"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Exercise-associated epigenetic remodeling and TCR repertoire dynamicsin Lynch Syndrome carriers (MEDIP-seq)","description":"Lynch Syndrome (LS) carriers are at elevated cancer risk. Recent data suggest exercise as a non-pharmacologic preventive strategy, yet the epigenetic and immunological mechanisms underlying its protective effects in this population remain unclear. Here, we perform integrative multi-omics profiling of DNA methylation, gene expression, and the T cell receptor (TCR) repertoire in LS carriers participating in a 52-week aerobic cycling intervention. We identify compartment-specific DNA methylation changes, including innate immune activation in cfDNA and oncogenic pathway repression in tissue. Transcriptomic integration highlights ISL1 as a key exercise-repressed gene and FLCN as a CRC-associated methylation target. TCR analysis reveals increased systemic repertoire diversity and tissue-specific clonal convergence, thus suggesting antigen-driven recruitment. These findings uncover epigenetic and immune remodeling as potential mechanisms of exercise-mediated protection in LS.","dates":{"publication":"2026/08/03"},"accession":"GSE310884","cross_references":{"GSM":["GSM9311139","GSM9311135","GSM9311136","GSM9311137","GSM9311138","GSM9311131","GSM9311132","GSM9311133","GSM9311134","GSM9311130","GSM9311146","GSM9311147","GSM9311148","GSM9311149","GSM9311142","GSM9311143","GSM9311144","GSM9311145","GSM9311140","GSM9311141","GSM9311117","GSM9311118","GSM9311119","GSM9311113","GSM9311114","GSM9311115","GSM9311116","GSM9311197","GSM9311110","GSM9311198","GSM9311199","GSM9311111","GSM9311112","GSM9311193","GSM9311194","GSM9311195","GSM9311196","GSM9311190","GSM9311191","GSM9311192","GSM9311128","GSM9311129","GSM9311124","GSM9311125","GSM9311126","GSM9311127","GSM9311120","GSM9311121","GSM9311122","GSM9311123","GSM9311216","GSM9311217","GSM9311218","GSM9311219","GSM9311179","GSM9311212","GSM9311213","GSM9311214","GSM9311215","GSM9311175","GSM9311176","GSM9311177","GSM9311210","GSM9311211","GSM9311178","GSM9311171","GSM9311172","GSM9311173","GSM9311174","GSM9311170","GSM9311209","GSM9311106","GSM9311107","GSM9311108","GSM9311109","GSM9311223","GSM9311224","GSM9311225","GSM9311226","GSM9311186","GSM9311220","GSM9311187","GSM9311188","GSM9311221","GSM9311222","GSM9311189","GSM9311182","GSM9311183","GSM9311184","GSM9311185","GSM9311180","GSM9311181","GSM9311157","GSM9311158","GSM9311159","GSM9311153","GSM9311154","GSM9311155","GSM9311156","GSM9311150","GSM9311151","GSM9311152","GSM9311205","GSM9311206","GSM9311207","GSM9311208","GSM9311168","GSM9311201","GSM9311202","GSM9311169","GSM9311203","GSM9311204","GSM9311164","GSM9311165","GSM9311166","GSM9311200","GSM9311167","GSM9311160","GSM9311161","GSM9311162","GSM9311163"],"GPL":["21290"],"GSE":["310884"],"taxon":["Homo sapiens"],"PMID":["[42701426]"]}}